TRA / QRA
Toxicological and quantitative risk assessment workflows.
ToxIntel · by Aᴳ
Scientific safety intelligence for beauty, wellness, and consumer brands.
Exposure-based safety, risk, and compliance intelligence — built for independent brands, growing brands, manufacturers, retailers, and enterprise organizations. Independent scientific review powered by Aᴳ.
Developed from real-world toxicology, retailer, and regulatory workflows.
Trusted by formulators, brands, and retailers
Independent brands · Contract manufacturers · Global retailers · Enterprise conglomerates
Platform capabilities
What ToxIntel delivers.
01
Toxicological risk assessment
Comprehensive TRA / QRA modeling with route-specific Margin of Safety calculations for global compliance.
02
Regulatory documentation
Retailer-ready dossiers mapped to MoCRA, EU 1223 Part A & B, Prop 65, IFRA, and major beauty retailers.
03
Formula screening
Proactive raw material, impurity, and contaminant evaluation against global restricted-substance lists.
04
Claim substantiation
Defensible scientific backing for safety, efficacy, and "free-from" claims across categories.
AI-assisted infrastructure. Toxicologist-governed review.
Every output operates within a scientific governance framework developed by Aᴳ.
Toxicological Intelligence Workspace
Toxicological Intelligence, Built for Real Product Decisions.
ToxIntel helps toxicologists, regulatory teams, brands, and legal partners move from scattered data to defensible safety conclusions. Search by ingredient name, CAS number, INCI name, or formula. ToxIntel organizes available toxicology and regulatory data, identifies relevant restrictions, highlights data gaps, and supports exposure-based decision-making across cosmetics, consumer products, and Proposition 65 workflows. Every output is designed to be source-traced, assumption-driven, and reviewable by a qualified toxicologist.
01
Ingredient intelligence search
Name, INCI, CAS, synonym, SMILES. Source-traced rows with date and citation.
02
Prop 65 screening + exposure modeling
Listed-substance status, MADL/NSRL surfaced, dermal + oral exposure scenarios.
03
Cosmetic safety substantiation support
EU 1223, UK CR, MoCRA-aligned. MoS context per category and product type.
04
Fragrance and IFRA review
Allergen disclosure rules, IFRA category limits, oxidation-control flags.
05
Regulatory framework comparison
Prop 65 · EU · UK · IFRA · MoCRA · Retailer RSLs — side-by-side with sources.
06
Data gap identification
Surfaces what's missing so you know what to commission, not just what's known.
07
Client-ready report generation
On-screen report cards today; PDF / Word export on the roadmap. (See ROADMAP)
Important compliance language
ToxIntel supports toxicology and regulatory review but does not replace qualified expert judgement. The platform does not automatically guarantee regulatory compliance and does not produce final legal conclusions. All outputs require review by a qualified toxicologist before use in safety substantiation, regulatory submission, or product release.
Scientific Governance
The operating system behind scientific decision-making.
Seven gates between an ingredient declaration and market access — each one source-traced, each one reviewable, each one signed.
- 01
Ingredients
Composition declared.
- 02
Hazard Review
Endpoints surfaced, cited.
- 03
Exposure Assessment
Route, scenario, dose.
- 04
Risk Characterization
MoS, severity, certainty.
- 05
Documentation
Source-traced dossier.
- 06
Regulatory Readiness
Prop 65 · EU · MoCRA · RSL.
- 07
Market Access
Defensible, reviewable.
Ingredients
01Composition declared.
Hazard Review
02Endpoints surfaced, cited.
Exposure Assessment
03Route, scenario, dose.
Risk Characterization
04MoS, severity, certainty.
Documentation
05Source-traced dossier.
Regulatory Readiness
06Prop 65 · EU · MoCRA · RSL.
Market Access
07Defensible, reviewable.
Every gate produces an auditable artifact. No black-box conclusions. Every output is reviewable by a qualified toxicologist.
The intelligence workflow
From formula to governance.
01Formula
02Exposure Review
03Risk Interpretation
04Documentation
05Governance
Engineered for serious operators
Scientific governance at the scale of a global portfolio.
From a single product launch to enterprise-wide formulation governance, ToxIntel adapts to where the work actually happens — without losing the rigor of toxicologist-signed review.
Governance architecture
Scaled intelligence from single formulas to global portfolios.
ToxIntel is engineered for the realities of where brands actually operate — not a one-size-fits-all enterprise contract.
01
Independent
Establish baseline safety and market readiness without enterprise overhead. Single Risk Screen or assessment, no commitment.
02
Growing
Retailer-ready documentation and complex exposure modeling for expanding product lines. Cross-formula governance.
03
Manufacturer
Ingredient screening and bulk compliance at the raw-material level. Supplier-side governance and reliability tiers.
04
Retailer
Vendor verification, marketplace governance, and overarching safety review for portfolios of third-party brands.
05
Enterprise
Comprehensive portfolio risk management, global MoCRA governance, API integration, and white-label delivery.
Scientific coverage
The scope of governance the platform supports.
Exposure modelling
Route-specific SED, NOAEL, and Margin of Safety derivation.
Packaging interaction review
Material-formula compatibility and migration governance.
Claims governance
Substantiation rationale for marketing and retailer claims.
MoCRA readiness
Operational alignment with US cosmetic regulation requirements.
IFRA alignment
Fragrance category mapping and concentration overlays.
Retailer documentation
Sephora · Credo · Whole Foods · Target · Ulta-aligned packs.
Ingredient intelligence
Hazard, restriction, and reliability-scored ingredient data.
Safety substantiation
Evidence assembly for product-safety conclusions.
Regulatory, retailer & marketplace readiness
Aligned with the standards modern brands navigate every day.
Scientific governance designed to support retailer onboarding, marketplace verification, and regulatory expectations across global jurisdictions.
MoCRAEU 1223Prop 65IFRASephoraCredoWhole FoodsTargetUltaHale
Reference
Safety & compliance terminology.
Brief, authoritative definitions of the scientific and regulatory work covered by the platform.
Cosmetic Safety Assessment
Comprehensive evaluation of cosmetic and personal care products to confirm they pose no risk to human health under normal and reasonably foreseeable conditions of use. Each assessment aligns to global standards (EU 1223 Part A & B, MoCRA, FDA, Health Canada), providing the scientific foundation for market entry, retailer onboarding, and regulatory defensibility.
Toxicological Risk Assessment (TRA)
Formalized hazard-and-exposure evaluation that quantifies the toxicological burden of each ingredient at the formulation level. We derive Points of Departure (PoD), apply route-specific uncertainty factors, and produce defensible Margin of Safety (MoS) calculations suitable for retailer review and regulatory submission.
Quantitative Risk Assessment (QRA)
Data-driven derivation of safe exposure thresholds — essential for sensitizers, fragrance allergens, and ingredients with dose-response endpoints. Our QRA models follow IFRA, SCCS, and OECD guidance to ensure formulas remain within scientifically validated safety boundaries across leave-on and rinse-off product categories.
Exposure-Based Risk Modeling
Dynamic modeling of how consumers actually interact with a product. We factor application area, daily frequency, retention factor, age cohort, and skin condition to calculate precise systemic exposure dose (SED), localized exposure, and aggregate cross-product exposure where relevant.
Ingredient Screening
Proactive evaluation of every raw material against global restricted substance lists, emerging chemicals of concern, and proprietary reliability tiers — before formulation begins. Outputs include risk-ranked ingredient profiles, alternative recommendations, and supplier-readable rationales.
Pregnancy & Breastfeeding Evaluations
Specialized toxicological reviews focused on reproductive, developmental, and lactation endpoints. We provide the scientific substantiation needed to address vulnerable consumer populations with confidence, including endocrine activity flags, placental transfer considerations, and clear use-during-pregnancy positioning.
Retailer Readiness Documentation
Turnkey compliance dossiers tailored to the specific scientific and documentary expectations of Sephora Clean, Credo Standard, Whole Foods Premium Body Care, Target Standards, and Ulta Conscious Beauty. We translate complex toxicological data into the exact formats demanded by each marketplace.
Product Safety Intelligence
Beyond compliance, ToxIntel delivers strategic intelligence — anticipating regulatory shifts, retailer policy updates, and consumer expectations. Each output is engineered to remain a trusted reference across the product lifecycle.
Regulatory Toxicology Support
Expert navigation of global chemical regulations: MoCRA (US), EU Cosmetic Regulation 1223/2009, Health Canada Cosmetic Notification, ASEAN harmonization, and California Proposition 65. We bridge scientific safety data with the legal compliance language required across jurisdictions.
Claims Substantiation
Scientific validation of safety and efficacy claims — from "dermatologist-tested" and "non-comedogenic" to "pregnancy-safe" and "free-from." We assemble the objective evidence required to defend marketing language against regulator and class-action scrutiny.
MoCRA Readiness
Operational alignment with the Modernization of Cosmetics Regulation Act. Adverse event reporting frameworks, safety substantiation files, responsible person designation, facility registration, and ingredient statement workflows — all delivered as audit-ready artifacts.
Supplier & Ingredient Governance
End-to-end oversight of the chemical supply chain. We help establish supplier safety standards, conduct raw-material reliability reviews, and provide ongoing governance so consistency and compliance are maintained at the source — not discovered downstream.
Comprehensive evaluation of cosmetic and personal care products to confirm they pose no risk to human health under normal and reasonably foreseeable conditions of use. Each assessment aligns to global standards (EU 1223 Part A & B, MoCRA, FDA, Health Canada), providing the scientific foundation for market entry, retailer onboarding, and regulatory defensibility.
Frequently asked
Common questions.
Begin
Bring scientific rigor to your brand.
A member of the Aᴳ team will respond within one business day to scope your specific category, jurisdiction, and timeline.