Beauty & Personal Care
From uploaded formula to MoCRA-ready substantiation — one governed workflow.
ToxIntel turns a cosmetic formula file into a governed safety record: extract, normalize, resolve every INCI against a peer-reviewed dossier, run exposure and MoS, screen every market for restrictions and Prop 65 hits, assemble the MoCRA Part A/B file, verify five retailer clean-standard overlays, and substantiate every claim — before the file leaves the toxicology team.
Where ToxIntel enters this work
The specific work this platform is built to serve.
- ◆Formula intake — upload a real-world CSV or Excel formula file in any column order. ToxIntel extracts every row, resolves each INCI against the governed ingredient registry (CAS-first, exact-INCI, synonym), sorts descending by concentration, validates the 100% total, and returns a clean review table.
- ◆Ingredient-level toxicology dossiers (INCI + CAS) — one governed record of truth reused across every product, every retailer overlay, and every claim. Every dossier carries chemistry, functions, endpoint evidence, and global regulatory posture.
- ◆Formula-level safety substantiation — governed NOAEL, dermal absorption, SED, and Margin of Safety (SCCS-aligned) computed against the resolved formula. Product-scenario defaults, population defaults, and reviewer overrides are all audit-logged.
- ◆MoCRA safety-substantiation file (Part A + Part B) assembled directly from the governed record — no double-entry, no separate spreadsheet.
- ◆IFRA-conformant fragrance handling with governed IFRA reference limits per product category; concentration breaches flagged pre-review.
- ◆California Prop 65 substance-list screening tied to the governed OEHHA mirror; safe-harbor logic applied where exposure data supports it.
- ◆Global compliance across US / EU / GB / CA / AU — fail-closed matrix screening against governed cosmetic-restriction datasets. Absence from a restriction list is NEVER treated as PASS.
- ◆Retailer-program readiness against Sephora Clean, Credo Clean Standard, Ulta Conscious Beauty, Target Clean, and Whole Foods Premium Body Care from one Compliance Passport per SKU.
- ◆Claim substantiation via the 7-stage Claims Intelligence workflow with FTC Green Guides + EU Green Claims Directive advisories attached to every draft.
- ◆Read-across and data-gap intelligence — when endpoint evidence is missing, the platform surfaces candidate analogues per endpoint with explainable Weight-of-Evidence, never similarity alone.
- ◆Reformulation impact — when a retailer updates an exclusion list or a regulator changes a category limit, every affected SKU, claim, and passport surfaces instantly.
The workflow, end to end
One governed workflow. Every step wired to the same evidence.
Step 01
Formula upload
CSV or Excel · any column order · trade names + supplier fields tolerated
Step 02
Ingredient resolution
CAS-first match against the governed registry; unresolved rows surfaced explicitly, never guessed
Step 03
Scientific evidence
Governed endpoint dossiers per INCI — Klimisch-scored, peer-reviewed sources, cross-module lineage
Step 04
Hazard & exposure
NOAEL + dermal absorption piped from the ingredient masterlist; SED and MoS computed against SCCS/IFRA-aligned scenario defaults
Step 05
Safety decision
Assessor Workspace signs the opinion with reviewer identity + audit-locked decision log
Step 06
Regulatory / market matrix
Fail-closed matrix across US · EU · GB · CA · AU; Prop 65 hits raised as ACTION; absence never treated as PASS
Step 07
Claims & retail readiness
7-stage Claims Intelligence review + 5-retailer Compliance Passport overlay in one governed record
Step 08
Governed record
Same record fuels MoCRA Part A/B, SDS, PIF/CPSR export, and every reformulation-impact re-run
Inside ToxIntel
See the technology behind the workflow.
Real, sanitized views from the live ToxIntel platform — no mockups, no fabricated data. Each screen below is what an authorized toxicologist, brand safety lead, or retailer reviewer actually works with every day.
Real, sanitized view · from the live platform
Formula intake · sample_formula.csv (13-row cosmetic serum) uploaded and normalized in one pass. ToxIntel resolved every INCI against the governed registry, arranged the working formula descending by concentration, validated TOTAL = 100%, and evaluated the US market: four real ACTION cells raised on Dibutyl Phthalate, Estragole, 1,4-Dioxane and Formaldehyde — each verified against the governed California Proposition 65 substance list. Every other cell is reported as INSUFF., a deliberate governance choice: absence from a restriction list is never converted into an unsupported PASS.
Open in ToxIntel →
Real, sanitized view · from the live platform
Ingredient Intelligence · Niacinamide (CAS 98-92-0) governed dossier: identity, chemistry, global regulatory status, and full scientific record consumed by every downstream module.
Open in ToxIntel →
Real, sanitized view · from the live platform
Read-across & data-gap intelligence · six evidence dimensions (structural, physicochemical, metabolic, endpoint relevance, Klimisch quality, regulatory context) scored on every candidate analogue. Weight-of-Evidence over similarity alone.
Open in ToxIntel →
Real, sanitized view · from the live platform
Centralized Exposure & MoS Engine · SCCS/IFRA-aligned product-scenario and population defaults; NOAEL and dermal absorption piped from the governed ingredient masterlist; every reviewer override audit-logged.
Open in ToxIntel →
Real, sanitized view · from the live platform
Compliance Passport · one governed record scored against Sephora Clean, Credo Clean Standard, Ulta Conscious Beauty, Target Clean and Whole Foods Premium Body Care overlays. Best-match framework + coverage %. Collect once. Verify once. Reuse everywhere.
Open in ToxIntel →
Real, sanitized view · from the live platform
Claims Intelligence · 7-stage governed review with the FTC Green Guides, EU Green Claims Directive, and clean-beauty class-action feed attached to every draft.
Open in ToxIntel →Every deep-link requires ToxIntel sign-in. Request an enterprise demo above and we'll walk you through them on live records.
What it maps to
Existing capabilities → where they enter your workflow.
| Existing capability | Where it enters your workflow |
|---|---|
| Formula Intake & Normalization | Any real-world CSV/XLSX layout accepted. Rows extracted, INCIs resolved CAS-first against the governed registry, formula sorted descending, 100% total validated. Nothing rescaled. Fail-closed continuation gate blocks downstream steps until every unresolved row is corrected. |
| Ingredient Intelligence (INCI + CAS) | Every INCI carries a governed dossier — chemistry, regulatory status by jurisdiction, endpoint evidence — reused across every assessment, retailer overlay, and claim. |
| Scientific Safety Assessment | Assessor Workspace signs the safety opinion with Klimisch-scored source review, cross-module lineage of every consumed data point, and reviewer-identity audit trail. |
| Centralized Exposure & MoS | Product-scenario + population defaults are SCCS/IFRA-aligned; NOAEL and dermal absorption flow from the ingredient masterlist; overrides are audit-logged with reviewer identity. |
| MoCRA Part A / Part B Substantiation | Adverse-event, ingredient-level toxicology, and formula-level safety records assemble into the substantiation file directly from the governed layer — no new spreadsheet. |
| IFRA Fragrance Handling | Governed IFRA reference tables applied to fragrance components in every product category; concentration breaches flagged pre-review. |
| California Prop 65 Screening | OEHHA governed mirror screens finished-good ingredient decks; hit surfaced as ACTION on the US column with the exact substance-list entry — verified live in the sample_formula.csv screen above (four real Prop 65 hits: Dibutyl Phthalate, Estragole, 1,4-Dioxane, Formaldehyde). |
| Global Compliance Matrix (US · EU · GB · CA · AU) | Fail-closed screening against the governed cosmetic-restriction datasets required for each market. INSUFFICIENT_DATA is emitted whenever a required dataset is not yet indexed — absence from a restriction list is never PASS. |
| Compliance Passport | One record — SDS, ingredient decks, packaging BOMs — scored against 5 retailer overlays and reused across brand portfolios. |
| Claims Intelligence | Every claim links to the scientific record that substantiates it; 7-stage governed review before it reaches legal or launch. |
| Read-Across & Data-Gap Intelligence | When endpoint evidence is missing, the platform surfaces candidate analogues per endpoint with explainable Weight-of-Evidence — never similarity alone. |
| SDS Generation (finished goods) | Governed classification + SDS drafting for finished cosmetic products where an SDS is required (bulk shipments, professional-use, export). |
| Reformulation Impact | Same governed dossier tracks the change and every downstream consequence across claims, passports, and retail readiness. |
Business outcomes
Buyer pathways in this vertical
Who arrives here — and what they use the shared core for.
Each pathway consumes the same shared ToxIntel core (Scientific Safety, Regulatory, Stewardship, Claims, Retail, Enterprise Risk) through the specific work actually done in this vertical.
Buyer
Brands
Indie founders through enterprise beauty houses use ToxIntel to run MoCRA safety substantiation, retailer readiness, and claim substantiation from one governed record — with beauty-market intelligence surfacing competitive claim positioning and retailer exclusion-list shifts before they force a reformulation.
Live capabilities used in this pathway
Formula Intake & Review
LiveUpload any CSV/XLSX; ToxIntel resolves INCIs, sorts descending, validates 100%, and surfaces per-market status on a single review screen.
Ingredient Intelligence
LiveGoverned INCI + CAS dossiers reused across every SKU; chemistry, global regulatory status, and endpoint evidence in one record.
Centralized Exposure & MoS
LiveSCCS/IFRA-aligned product-scenario defaults; NOAEL and dermal absorption flow from the ingredient masterlist.
MoCRA Substantiation File
LivePart A adverse-event workflow + Part B safety substantiation assemble from the same governed records — export-ready.
Compliance Passport (5 retailer overlays)
LiveSephora Clean, Credo Clean Standard, Ulta Conscious Beauty, Target Clean, Whole Foods Premium Body Care — best-match framework + coverage %.
Claims Intelligence
Live7-stage governed review with FTC Green Guides and EU Green Claims Directive advisories attached to every draft.
Prop 65 Screening
LiveOEHHA governed mirror applied to every ingredient deck; ACTION cells raised on CAS matches (verified in the sample_formula screenshot above).
Beauty-market Intelligence
LiveRetail-compliance feed + claims-intelligence feed surfacing exclusion-list shifts, class-action patterns, and jurisdictional posture across US / EU / UK / CA.
SDS Generation (finished goods)
LiveGoverned classification + SDS drafting for finished cosmetic products where an SDS is required.
Deep-link into the platform
See how it fits your team.
A 30-minute session on live records — no slides. Bring the workflow question you actually need answered this quarter.
Shared core capabilities applied in this workflow
Explore other industries